Fig. 1

Overview of total biosynthetic gene clusters (BGCs) and distribution of RiPPs in the selected species. (a) Relative abundance of the 6,642 BGCs identified in our dataset. RiPPs constitute 17% of the total BGCs. Other major BGC classes detected are - PKSs: Polyketide synthases; NRPSs: nonribosomal peptide synthetases; terpenes and Hybrid: hybrid chemical products of nonribosomal peptides and polyketide synthases. (b) A phylogenetic tree inferred from universal single-copy genes showing the distribution of RiPP biosynthetic gene clusters across taxa, depicted as blue bars. Genome completeness (G. completeness) is shown using a heatmap. The number of RiPP BGCs varies greatly among lichen-forming fungi.